Myristic acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

肉豆蔻酸是一种 14 碳饱和脂肪酸，是细胞中的稀有分子，是某些脂肪酸去饱和酶的底物。

Myristic Acid, a 14 carbon saturated fatty acid, is a rare molecule in cells and is a substrate of some fatty acid desaturases. This compound has the ability to acylate proteins by covalently binding to the N-terminal glycine residues, in a process called N-terminal myristoylation. Myristoylation of substrate proteins by this fatty acid has the potential to activate and mediate many physiological pathways. Furthermore, saturated fatty acids have been reported to be essential for biological activities of lipopolysaccharides and have demonstrated the ability to induce expression of COX-2 and NFκB (nuclear factor κB) activation.

Western Blot Analysis Cell Line:MAC-T Concentration:100, 150, 200 μM Incubation Time:24 h Result:Increased the level of protein ubiquitination.Cell Viability Assay Cell Line:J774A.1 macrophages Concentration:12.5, 25, 50, 100,200 μg/mL Incubation Time:24 h Result:Showed non-cytotoxic effects in LPS-stimulated J774A.1 macrophages at 25 μg/mL.

Animal Model:TPA-induced ear edema in miceDosage:12.5, 25, 50, 100 mg/kg Administration:p.o.Result:Decreased ear edema inflammation in the acute and chronic TPA assays with IC50 values of 62 and 77 mg/kg, respectively in a dose-dependent manner.Attenuated the acetic acid-induced abdominal contortions with ED50 values of 32 mg/kg.

——

Others

Other Targets

Others

——

——

544-63-8

228.38

C14H28O2

>98% (HPLC)

DMSO : ≥ 250 mg/mL; 1094.71 mM

O=C(O)CCCCCCCCCCCCC

——

(-20℃)

With Ice Pack

≥ 2 years