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Myristic acid

CAS No. 544-63-8

Myristic acid ( —— )

产品货号. M18773 CAS No. 544-63-8

肉豆蔻酸是一种 14 碳饱和脂肪酸,是细胞中的稀有分子,是某些脂肪酸去饱和酶的底物。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
500MG ¥316 有现货
1G ¥381 有现货

生物学信息

  • 产品名称
    Myristic acid
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    肉豆蔻酸是一种 14 碳饱和脂肪酸,是细胞中的稀有分子,是某些脂肪酸去饱和酶的底物。
  • 产品描述
    Myristic Acid, a 14 carbon saturated fatty acid, is a rare molecule in cells and is a substrate of some fatty acid desaturases. This compound has the ability to acylate proteins by covalently binding to the N-terminal glycine residues, in a process called N-terminal myristoylation. Myristoylation of substrate proteins by this fatty acid has the potential to activate and mediate many physiological pathways. Furthermore, saturated fatty acids have been reported to be essential for biological activities of lipopolysaccharides and have demonstrated the ability to induce expression of COX-2 and NFκB (nuclear factor κB) activation.
  • 体外实验
    Western Blot Analysis Cell Line:MAC-T Concentration:100, 150, 200 μM Incubation Time:24 h Result:Increased the level of protein ubiquitination.Cell Viability Assay Cell Line:J774A.1 macrophages Concentration:12.5, 25, 50, 100,200 μg/mL Incubation Time:24 h Result:Showed non-cytotoxic effects in LPS-stimulated J774A.1 macrophages at 25 μg/mL.
  • 体内实验
    Animal Model:TPA-induced ear edema in miceDosage:12.5, 25, 50, 100 mg/kg Administration:p.o.Result:Decreased ear edema inflammation in the acute and chronic TPA assays with IC50 values of 62 and 77 mg/kg, respectively in a dose-dependent manner.Attenuated the acetic acid-induced abdominal contortions with ED50 values of 32 mg/kg.
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    544-63-8
  • 分子量
    228.38
  • 分子式
    C14H28O2
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : ≥ 250 mg/mL; 1094.71 mM
  • SMILES
    O=C(O)CCCCCCCCCCCCC
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Lee JY,etal.Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J Biol Chem. 2001 May 18;276(20):16683-9.
产品手册
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